BEAUACTIVE® [Fermented Ginseng and Nukadoko]

Fermented ginseng contains 10-Hydroxystearic acid and has numerous health benefits, including anti-aging benefits “Nukadoko“ naturally fermented rice bran mash traditionally used for pickling vegetables in Japan contains 10-Hydroxystearic acid BEAUACTIVE® can be suitable to treat conspicuous facial pores and age spots.

BEAUACTIVE® multi-target mode of action

BEAUACTIVE®

Strong efficacies in vitro and ex vivo

BEAUACTIVE®

marked p53 reduction ex vivo

BEAUACTIVE®

significantly reduced surface of conspicouous facial pores

BEAUACTIVE®

visibly reduced age spot contrast

CROSS-POLARIZED IMAGES:

COTTON STEM CELLS [Gossypium herbaceum]

It offers global protection against UV radiation, Atmospheric pollutants, and heavy metals. The skin is protected form oxidative stress, pollution, and signs of aging while preserving celluar viability.

EYE’FECTIVE™ [ARABIAN JASMINE, Jasminum sambac / HAWTHORN, Crataegus monogyna]

Native to the south of the Himalayas. Its name comes from the Persian word "yasamin" which means "Gift of God". Rich in iriboid glycosides and flavonoids, traditionally used for its anti-inflammatory and anti-tyrosinase activites. Native to Europe, Known in Victorian times as the flower of hope, Rich in flavonoids and traditionally used to treat circulatory problems.

IN VIVO EFFICACY

PANEL 2 / Upper eyelid lifting effect Measurement of pretarsal skin distance (P) on the upper eyelid. Low P indicates sagging and droopy eyes.

IBR-UrBioTech ™ [ELECAMPANE SEEDS, Inula helenium]

Anti-oxidative and Anti-inflammatory power. Inula helenium extract is able to protect the skin from urban pollution & blue light damage for healthy, radiant, hydrated and smooth skin.

POLLUTION: HOW IT AFFECTS THE SKIN

Urban pollution is a real threat to the skin

Our atmosphere and surroundings are increasingly becoming more toxic with harmful chemicals and radiation being emitted into the atmosphere every day. Some of these pollutants include polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), oxides, particulate matter (PM), ozone (O 3 ), cigarette smoke as well as blue light that is emitted from most electronic devices surrounding us. It weakens the skin barrier, accelerates inflammation response, and elevate pigmentation which leads to premature signs of aging, dryness, wrinkling, sagging, loss of elasticity and irritation.

PhytoCellTec™ [GRAPE, Solar vitis]

Solar Vitis is based on stem cells derived from a specific grape cultivar that has been obtained through a unique PhytoCellTec™ technology. The activity of skin stem cells ensures the vitality and regeneration capacity of the skin. PhytoCellTec™ technology and Solar Vitis both protect and maintain the activity of epidermal stem cells - even in cases of stress induced by UV.

CITRUSTEM™ [ORANGE, Citrus sinensis]

CITRUSTEM™ is produced from stem cells obtained from the orange (Citrus sinensis). These stem cells contain amino acids, especially proline and betaines. CITRUSTEMTM, obtained from orange stem cells, increases the expression of genes capable of improving the structure of the extracellular matrix.

CITRUSTEM™ organizes and redensifies the dermis structure, by increasing the synthesis of the elements forming the extracellular matrix. A structured dermis translates into a regular and defined microrelief. The skin recovers its smooth and velvety feel. The skin appears renewed, wrinkles are reduced, and its global aspect is improved. It looks younger.

With CITRUSTEM™, the skin regains the elastic properties of skin 12 years younger.

Orchistem™ [ORCHID,Phalaenopsis]

Eleven phenolic compounds were identified, namely,protocatechuic acid, p-hydroxybenzoic acid, vanillic acid, caffeic acid, syringic acid, vanillin, ferulic acid, sinapic acid, p-coumaric acid, benzoic acid, and ellagic acid. Ferulic, p-coumaric and sinapic acids were concentrated largely in the roots.

Orchistem™ LIFTING SERUM

Orchistem ™ improve firmness and elasticity and revives the complexion with a youthful, looking glow

Orchistem™, tackles the signs of ageing, to lift and firm skin, fight wrinkles, and give back a glowing radiance

IN VIVO/Clinical evaluation of eyelid lifting and wrinkles (after 56 days)

An expert dermatologist evaluated:

PhytoCellTec™ Alp Rose [ROSE, Rhododendron frrugineum]

By optimizing the potential of epidermal stem cells, PhytoCellTec™ Alp Rose (Rhododendron ferrugineum) improves epidermal regeneration and thus the quality of the skin barrier. Alp Rose strengthens the skin barrier and makes it more environmental stresses such as UV rays, wind, cold temperatures and dryness. A clinical study performed in the Alps during winter confirmed the capacity of PhytoCellTec™ Alp Rose to reinforce the skin barrier and to reduce aging signs (wrinkles, redness, loss of radiance).

Claim Ideas for PhytoCellTec™ Alp Rose

• Increases skin stem cell vitality
• Boosts epidermal regeneration
• Improves the skin barrier function
• Helps the skin to cope with climate changes

IBR-Snowflake® [SPRING SNOWFLAKES, Leucojum aestivum Bulb]

Roots are full of moisture, and in southern Europe and elsewhere they are used as plant prescriptions. It also has a great antioxidant effect and helps restore fine wrinkles and ageing of the skin.

Clinical efficacy study - anti-wrinkle and anti-ageing

The test was done in France on 21 healthy female volunteers aged 42-64 (median 60) in March 2009; the test was designed as a double-blind placebo-controlled and in randomized hemiface application;

The number of microrelief furrows decreased by 30% and 86% of the panelists had a reduction;

The number of medium-depth wrinkles decreased by 15% and 62% of the panelists had a reduction; (*Results vs placebo are highly significant p<0.05; Results vs placebo significant p<0.07)

IBR-Snowflake® 2% concentration in a simple elixir base, applied twice a day for 28 days.
Skin Image Analyser® and PRIMOS® measurements of the wrinkles.

Improvement of wrinkles 3D image using PRIMOS with the use twice a day of an elixir containing 2% IBR-Snowflake®

IBR-Snowflake® 2% concentration in a simple cream base, applied twice a day for 28 days. Skin Image Analyser® and PRIMOS® measurements of the wrinkles.
After 28 days of Usage, the skin of 21 healthy female applicants saw a 30 percent decrease in fine wrinkles, and 86 percent of the participants showed this result.

SulforaWhite® Detoxophane (Lepidium sativum Sprout Extract )

Cress Liposomes effectively inhibit pigmentation by targeting two key upstream reaction steps in the melanin cascade:

Cress Liposomes effectively inhibits pigmentation by targeting two key upstream reactionsteps in the melanin cascade:

• Neutralization of reactive oxygen species
• Inhibition of α-MSH, a natural hormone that stimulates skin pigmentation.

The whitening effect of cress liposomes was proven both in vitro and in vivo.

• Effectively inhibits melanin formation
• Provides exceptional brightening benefits
• Fades the appearance of dark spots and discolorations
• Reduces the effects of daytime stressors
• Evens skin tone

VOTASPIRCE™ [BAICALIN, Scutellaria baicalensis]

Perennial plants, coming from Asia, are used in traditional medicine. A purified fraction obtained from the roots of Scutellaria baicalensis Georgi, standardized in baicalin.

• Delays senescence, increasing fibroblast duplications number by 10%.
• Restructures skin microrelief decreasing anisotropy by 13%.
• Increases the values of skin elasticity and firmness.
• Recovers characteristics that skin cells had 10 years earlier.

CELLULAR SENESCENCE

• Senescence is a synonym for aging.
• As years pass, cells diminish their replicative capacity, reducing their number of duplications a 10% every decade

IN VITRO EFFICACY

Effect on duplications

• In vitro test showed that fibroblasts treated with Vitasource™ reach 5 additional cell divisions.
• Considering that fibroblasts duplicate around 50 times, this means 10% more.
• If the decline in duplication is 10% every 10 years, this means RECOVERING 10 YEARS.

Vitasource™ rejuvenates skin to a condition comparable to that of one decade younger

IN VITRO EFFICACY

Skin microrelief

• Anisotropy (skin disorganization)

With VitasourceTM, anisotropy diminishes a 13% respect placebo.

The skin relief improves, skin is restructured for a youthful complexion

CHLORELLA

Pharmaceutically Grown Pure Chlorella™ (soft cell wall) 100% certified organic Klamath Lake (AFA) and Spirulina

Pure Spirulina and Pure Chlorella, are similar, each of these species has a special nutritional component to offer. Spirulina is one of the only food sources of GLA (gamma linoleic acid), the essential fatty acid precursor to PGE1. Chlorella contains CGF (chlorella growth factor) and is the richest source of nucleic acids, including RNA/DNA, available.

AFA has 12 vitamins, 27 naturally occurring or magnesium, zinc, the calcium of essential minerals, and 11 pigments some of which are precursor to other B vitamins, enzymes, co-enzymes, beta-carotene, bioflavonoids, RNA, superoxide dismutase, catalase, glutathione, selenium, and cysteine, making AFA one of the highest known sources of naturally occurring anti-oxidants or free radical scavengers.

OPTIM HYAL™

OPTIM HYAL™ contains Glycokines™ that mimic biological messengers. Obtained by fermentation, Glycokines™ are oligosaccharides bio-available and rich in the same monosaccharide as hyaluronic acid.

With OPTIM HYAL™, the average density and depth of the main wrinkles are significantly reduced.

OPTIMAL AND SUSTAINED HYALURONIC ACID NEOSYNTHESIS
⇒ Hyaluronic acid production
Hyaluronic acid on keratinocytes: +85%, p<0.01
Hyaluronan synthase-2 on fibroblasts: +90.5%, p<0.01
Hyaluronic acid on fibroblasts:+35%, p<0.01

⇒ Hyaluronic acid receptor expression
Hyaluronic acid receptor CD44 on explants: +55%, p<0.02

ELASTIN SYNTHESIS
Elastin on fibroblasts: +552%, p<0.01
Elastin on explants: +18%, p<0.04